Interconnected Science: Gioele Pecin on Fungal Molecules and the Power of Collaboration

For Gioele Pecin, understanding how fungi produce biologically active molecules is more than just scientific curiosity — it’s a complex and collaborative journey. As part of the MAGic-MOLFUN network, he’s studying how nonribosomal peptide synthases contribute to the biosynthesis of fungal lipopeptides, a promising class of natural compounds. In this interview, Gioele reflects on the unexpected challenges of staying organized in the lab, the deep interconnection of disciplines in natural product research, and the professional growth made possible through international collaborations.

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Gioele’s project, “Boosting the discovery of novel fungal natural products,” focuses on unlocking the potential of cyclic peptides and depsipeptides from underexplored fungal species. Using a combination of genome analysis, metabolomics, and fermentation studies, he investigates how nonribosomal peptide synthases and other biosynthetic gene clusters coordinate the production of these complex compounds. His work aims to identify and optimize promising molecules with potential pharmaceutical applications, contributing to the broader goal of uncovering nature’s hidden chemical diversity.